Dr. Catherine Brissette, Ph.D.
University of North Dakota
Study (2021): “Cerebrospinal Immune Response in a Tractable Murine Model of Lyme Neuroborreliosis”
Lyme neuroborreliosis (LNB) occurs in 10–15% of Lyme disease cases. Although much progress has been made in diagnostic LNB research using clinical specimens, there is still an urgent need for a tractable animal model that can be utilized to study the pathobiology of LNB. Dr. Brissette’s team has developed a model of LNB using C3H mice, and their long-term goal is to utilize this model to identify pathogen, host, and environmental factors that trigger central nervous system involvement in order to develop new prophylactic and therapeutic treatments for LNB. Additionally, this study will determine markers of infection and/or inflammation in the cerebrospinal fluid (CSF) of infected mice, which could serve as inflammatory signals to the brain. Such biomarkers, if present in human CSF, might be indicative of continued infection.