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Request for Proposals

The request for proposals for the Global Lyme Alliance 2022 – 2023 funding cycle is now open. The submission process begins with this solicitation for letters of intent (LOI). Only applicants whose LOI is in programmatic alignment with GLA’s research priorities will be invited to submit a full proposal.

Small-scale grants for proof-of-concept studies lasting one year can be requested for between $50,000 and $100,000. Full-scale grants may request larger amounts, up to $175,000 per year for up to 2 years.


Scientists and clinicians from accredited degree-granting academic or not-for-profit institutions are eligible to apply. Applicants typically have M.D. and/or Ph.D. degrees, although other certifications of higher learning are also considered. Prior GLA-funded investigators in good standing are also eligible.

Research Priorities

Lyme disease

Proposals focused on Lyme disease, particularly host immunology/immune dysregulation with an emphasis on post-treatment Lyme disease, direct diagnostics and improved treatment strategies are encouraged. Molecular biology and bioinformatics-oriented proposals are also considered. Another area of programmatic interest is bacteriophage biology as it relates to 1) regulation of Borrelia burgdorferi virulence, 2) Lyme disease pathogenesis, 3) and the potential use of bacteriophage for diagnosis and treatment of Lyme disease.


Priority will be given to proposals that address critical needs in diagnostics and treatment. Proposals exploring potential associations between Bartonellosis and neuroinflammation and neuropsychiatric disorders are of particular interest.

LOI instructions

A single-spaced, one-page document with Arial 11-point font and 0.5-inch margins is acceptable. A brief description of the proposal’s significance, aims, proposed experiments, key preliminary findings and/or figures, and potential impact on patients should be included. A short list of references can be provided on a separate page. The project title and submitter’s name must be clearly stated. All LOIs must adhere to these guidelines for consideration. An LOI template will be available online. Click here for full instructions. 

LOI submission deadline

An online portal to submit LOIs will be opened on the GLA website on August 1, 2022 and will close at 11:59 pm EST on September 15, 2022. All applicants will be notified by November 1, 2022 whether they will be invited to apply with a full proposal.