Findings have major implications for tick-borne diseases like Lyme disease
Researchers have uncovered a mechanism by which the bacteria that cause Lyme disease persist in the human body and fight the body's early, innate immune responses. Dr. Utpal Pal, Professor in Veterinary Medicine at the University of Maryland (UMD), has been studying the Borrelia burgdorferi bacteria throughout his 12 years with UMD, and his work has already produced the protein marker used to identify this bacterial infection in the body. Now, Dr. Pal has isolated a protein produced by the bacteria that disables one of the body's first immune responses, giving insight into mechanisms that are largely not understood.
- Quentin Bernard, Alexis A. Smith, Xiuli Yang, Juraj Koci, Shelby D. Foor, Sarah D. Cramer, Xuran Zhuang, Jennifer E. Dwyer, Yi-Pin Lin, Emmanuel F. Mongodin, Adriana Marques, John M. Leong, Juan Anguita, Utpal Pal. Plasticity in early immune evasion strategies of a bacterial pathogen. Proceedings of the National Academy of Sciences, 2018; 201718595 DOI: 10.1073/pnas.1718595115