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Many people who are fighting Lyme disease also suffer from depression.

“Maybe you’re just depressed.”

It’s a line many Lyme patients have heard from family, friends, co-workers, and even physicians. Particularly for those struggling with undiagnosed Lyme disease, this suggestion is a popular “answer” when patients don’t otherwise fit into an easy diagnostic box. When I was first wrestling with symptoms of tick-borne illness at age 19, a nurse at my college health center said, “Maybe you should see someone in counseling about all of this” when she tired of my frequent visits for hypoglycemia, fatigue, headaches and fevers. At such an impressionable age, I worried she was right.

In some ways, she was. Seeing a counselor might have helped me work through the complex emotions of being sick, not having a diagnosis, and not being able to keep up with my peers academically or socially. Later, when I was being properly treated for Lyme disease, babesiosis, ehrlichiosis, possible bartonella, and chronic active Epstein-Barr virus, a therapist was an important part of my support system.

But seeing a therapist wouldn’t have solved my physical ailments, because depression was an effect of them, not the cause. Anyone who suffers from a long-term illness, who wakes up day after day feeling like they never slept, who can’t get out of bed, is bound to get depressed. For some people, chemical depression is indeed the diagnosis that causes both mental and physiological symptoms. For Lyme disease patients, however, depression is a symptom of that tick-borne infection.

A recent study by Dr. Michael Eriksen of Copenhagen University and Dr. Brian Fallon of Columbia University showed an increased risk of psychiatric illness in Lyme disease patients. Collecting data from over 7 million Danish people over 22 years—including 12,000 people diagnosed with Lyme disease—the researchers found that with a single diagnosis of Lyme disease, there is a 24% increased risk of any mental disorder, including depression. Two or more episodes of Lyme disease increases that risk to 79%. This elevated potential for mental disorders was highest in subjects ages 20-29. Having struggled with depression throughout college and my early twenties, both as a side effect of being sick and as a side effect of Lyme disease itself, I can certainly attest to the particular vulnerability of young people.

Whatever a Lyme disease’s patient’s external situation, the mechanisms of the disease going on in their body can cause depression. This is especially true with neurological Lyme disease, when the Lyme bacteria (spirochetes) have crossed the blood-brain barrier, causing inflammation in the central nervous system. This inflammation can lead to a host of psychiatric manifestations. As psychiatrist Robert Bransfield, M.D. notes in his paper “Neuropsychiatric Lyme Borreliosis: An Overview with a Focus on a Specialty Psychiatrist’s Clinical Practice,” “Lyme Borreliosis causes immune and metabolic effects that result in a gradually developing spectrum of neuropsychiatric symptoms, usually presenting with significant comorbidity which may include developmental disorders, autism spectrum disorders, schizoaffective disorders, bipolar disorder, depression, anxiety disorders (panic disorder, social anxiety disorder, generalized anxiety disorder, posttraumatic stress disorder, intrusive symptoms), eating disorders, decreased libido, sleep disorders, addiction, opioid addiction, cognitive impairments, dementia, seizure disorders, suicide, violence, anhedonia, depersonalization, dissociative episodes, derealization and other impairments.”[i]

If this list seems scary, don’t despair. While Lyme disease, especially when complicated by co-infections, can have devastating effects, those effects can also improve significantly with proper treatment. Antibiotics and complementary therapies helped me battle my tick-borne illnesses into remission. While I do still struggle at times with anxiety and depression, they are much better than they were when I was first sick. Talk therapy, medication, and cognitive behavioral therapy have all helped. So has understanding the derivation of my anxiety and depression, and recognizing that when they do flare up, it generally means that Lyme disease symptoms are flaring, too. For example, I have noticed that when I get over tired, I get very sad. Nothing external triggers this sadness; it’s brought on by inflammation and fatigue. Rest—and occasionally small tweaks to my protocol—help me get back on track.

If you have depression as part of tick-borne illness, please know that this is normal, and that there is help. Speak with your Lyme Literate Medical Doctor (LLMD) about psychiatric treatment and/or talk therapy, and know that things can get better. I am living proof.

[i] Bransfield RC. Neuropsychiatric Lyme Borreliosis: An Overview with a Focus on a Specialty Psychiatrist’s Clinical Practice. Healthcare. 2018; 6(3):104. https://doi.org/10.3390/healthcare6030104

Related Topics:

"Global Lyme Alliance Funds Groundbreaking Study Linking Lyme Disease to Psychiatric Disorders."

Lyme Disease and Anxiety

Lyme Disease and Mental Disorders: It’s Not All in Your Head


Jennifer Crystal


Opinions expressed by contributors are their own. Jennifer Crystal is a writer and educator in Boston. Her work has appeared in local and national publications including Harvard Health Publishing and The Boston Globe. As a GLA columnist for over six years, her work on GLA.org has received mention in publications such as The New Yorker, weatherchannel.com, CQ Researcher, and ProHealth.com. Jennifer is a patient advocate who has dealt with chronic illness, including Lyme and other tick-borne infections. Her memoir, One Tick Stopped the Clock, is forthcoming from Legacy Book Press in September 2024. Ten percent of proceeds from the book will go to Global Lyme Alliance. Contact her via email below.

Email: lymewarriorjennifercrystal@gmail.com